Recent Publications

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The following is a compilation of publications from the past 3 years:

Kang, S.-H., Huang, J., Lee, H.-N., Hur, Y.-A., Cohen, S. N., and Kim, E.-S. Interspecies DNA Microarray Analysis Identifies WblA as a Pleiotropic Down-regulator of Antibiotic Biosynthesis in Streptomyces. J. Bacteriol. Epub 2007 Apr 6.

Fong, R., Hu, Z., Hutchinson, C.R., Huang, J., Cohen, S.N., and Kao C. Characterization of a Large, Stable, High Copy Number Streptomyces Plasmid That Requires Stability and Transfer Functions for Heterologous Polyketide Overproduction. Appl. Environ. Microbiol. 73:1296-307, 2007. Epub 2006 Dec 1.

Cheng, T.-H. and Cohen, S.N. Human MDM2 isoforms translated differentially on constitutive vs. p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops. Mol. Cell. Biol. 27:111-9, 2007. E-pub 23 October 2006.

Caruthers, J.M., Feng, Y., McKay, D.B., Cohen, S.N. Retention of core catalytic functions by a conserved minimal ribonuclease E peptide that lacks the domain required for tetramer formation. J. Biol. Chem. 281:27046-27051, 2006.

Chang, A.C.Y., Zsak, L., Feng, Y., Mosseri, R., Lu, Q., Kowalski, P., Zsak, A., Burrage, T.G., Neilan, J.G., Kutish, G.F., Lu, Z., Laegreid, W., Rock, D.L., Cohen, S.N. Phenotype-based identification of host genes required for replication of African swine fever virus. J. Virol. 80:8705-8717, 2006.

San Paolo, S., Huang, J., Cohen, S.N., Thompson, C.J. rag genes: novel components of the RamR regulon that trigger morphological differentiation in Streptomyces coelicolor. Mol. Microbiol. 61:1167-1186, 2006.

Lih, C.J., Wei, W., Cohen, S.N. Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. Genes Dev. 20: 2082-2095, 2006.

Tamura, M., Lee, K. Miller, C.A., Moore, C.J., Shirako, Y., Kobayashi, M., Cohen, S.N. RNase E maintenance of proper FtsZ/FtsA ratio required for non-filamentous growth of Escherichia coli cells but not for colony forming ability. J. Bac. 188:5145-5152, 2006.

Gao, J., Lee, K., Zhao, M., Qiu, J., Zhan, X., Saxena, A., Moore, C.J., Cohen, S.N., Georgiou, G. Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome. Mol. Microbiol. 61:394-406, 2006.

Wei, W., Lu, Q., Chaudry, G.J., Leppla, S.H., Cohen, S.N. The LDL Receptor-Related Protein LRP6 Mediates Internalization and Lethality of Anthrax Toxin. Cell. 124(6):1141-54, 2006.

Huang, J., Shi, J. Molle, V., Sohlberg, B., Weaver, D., Bibb, M., Karoonuthaisiri, N., Lih, C.-J., Kao, C.M., Buttner, M.J., Cohen S.N. Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor. Mol. Microbiol., 58: 1276-1287, 2005.

Pan K.-H, Lih C.-J, Cohen S.N.. Effects of threshold choice on biological conclusions reached during analysis of gene expression by DNA microarrays. Proc. Natl. Acad. Sci. USA 102(25): 8961-8965, 2005.

Patil M.A., Chua M.-S., Pan K.-H., Lin R., Lih C.-J., Cheung S.T., Ho C., Li R., Fan S.T., Cohen S.N., Chen X., So S. An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma. Oncogene, 24: 3737-47, 2005.

Lu, Q., Wei, W., Kowalski, P.E., Chang, A.C.Y. and Cohen, S.N. EST-based genome-wide gene inactivation identifies ARAP3 as a host protein mediating cellular susceptibility to anthrax toxin. Proc. Natl. Acad. Sci. USA, 101: 17246-51, 2004.

Zhang, H. and Cohen, S.N. Smurf2 up-regulation activates telomere-dependent senescence. Genes and Development, 18: 3028-40, 2004.

Bao, K. and Cohen, S.N. Reverse transcriptase activity innate to DNA polymerase I and DNA topoisomerase I proteins of Streptomyces telomere complex. Proc. Natl. Acad. Sci. USA, 101: 14361-6, 2004.

Miller, C., Thomsen, L.E., Gaggero, C., Mosseri, R., Ingmer, H. and Cohen, S.N. SOS response induction by beta-lactams defends bacteria against antibiotic lethality. Science, 305: 1629-31, 2004.

Zhang, H., Herbert B.-S., Pan, K.-H., Shay, J.W., and Cohen, S.N. Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions. Oncogene, 23: 6193-6198, 2004.

Bernstein, J.A., Lin, P.-H., Cohen, S.N. and Lin-Chao, S. Global analysis of E. coli RNA degradosome function using DNA microarrays. Proc. Natl. Acad. Sci. USA, 101: 2758-63, 2004.

Weaver, D., Karoonuthaisiri, N., Tsai, H.H., Huang, C.H., Ho, M.L., Gai, S., Patel, K.G., Huang, J., Cohen, S.N., Hopwood, D.A., Chen, C.W., and Kao C.M. Genome plasticity in Streptomyces: identification of 1 Mb TIRs in the S. coelicolor A3(2) chromosome. Mol Microbiol., 51: 1535-50, 2004.



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